A 28 years old white female presents with ascending numbness and weakness in both feet, slightly symmetrically, over a period of 2 weeks. Patient history reveals a 3-week history of unilateral hemibody paresthesias during finals week in college 6 years ago. Since then, she reports occasionally having some tingling on that side if she is overly tired, stressed, or hot. What are the most important differential diagnoses?

Of the relevant differential diagnoses, it is important to rule out vitamin B12 deficiency, acute disseminated encephalomyelitis and syphilis.

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This post was written by Omar Rifai